RAF Typhoon jets have operated alongside French warplanes in a combined operation on an underground arms cache in Syrian territory used by the IS group, per a report from the British defence ministry.
The site, located using intelligence, was believed to be storing arms and explosives, the statement said, and was situated in mountains just to the north of Palmyra in Syria's central region.
"The RAF jets utilized laser-guided Paveway IV weapons to strike a number of entry passages down to the depot... preliminary assessments suggest the target was engaged successfully," the ministry announced.
There was no sign of any civilian impact in the attack late on Saturday and all the aircraft made a safe return, the ministry further stated.
The British jets were assisted by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - imposed jihadist rule over significant areas in Syria and Iraq until 2019.
"This operation underscores our UK leadership, and determination to stand shoulder to shoulder with our allies, to stamp out any resurgence of IS and their dangerous and violent ideologies in the region," Britain's Defence Chief the minister stated.
RAF aircraft have carried out patrols over Syria to "deter any attempted resurgence" of IS following its defeat at the Baghuz confrontation in the year 2019, the MoD reported.
"I want to thank the personnel of our armed forces involved in this operation for their expertise and their valour," he said. "They were among a great many UK service members deployed over the festive period. This mission, to remove dangerous terrorists who threaten our safety, demonstrates how British military are prepared to act, continuously, ensuring Britain's security within its borders and influential overseas."
In December, the US military carried out what it described as a "massive strike" against IS targets in the country, following an ambush resulted in the deaths of two US troops and a local interpreter in Palmyra.
The UN reports IS still boasts an estimated 5,000 to 7,000 militants in both countries.